The transmembrane cation channel superfamily was defined in
InterPro
InterPro is a database of protein families, protein domains and functional sites in which identifiable features found in known proteins can be applied to new protein sequences in order to functionally characterise them.
The contents of InterPro c ...
and
Pfam as the family of
tetrameric
A tetramer () (''tetra-'', "four" + ''-mer'', "parts") is an oligomer formed from four monomers or subunits. The associated property is called ''tetramery''. An example from inorganic chemistry is titanium methoxide with the empirical formula T ...
ion channels. These include the
sodium
Sodium is a chemical element with the symbol Na (from Latin ''natrium'') and atomic number 11. It is a soft, silvery-white, highly reactive metal. Sodium is an alkali metal, being in group 1 of the periodic table. Its only stable ...
,
potassium
Potassium is the chemical element with the symbol K (from Neo-Latin ''kalium'') and atomic number19. Potassium is a silvery-white metal that is soft enough to be cut with a knife with little force. Potassium metal reacts rapidly with atmosph ...
,
calcium
Calcium is a chemical element with the symbol Ca and atomic number 20. As an alkaline earth metal, calcium is a reactive metal that forms a dark oxide-nitride layer when exposed to air. Its physical and chemical properties are most similar t ...
,
ryanodine receptor,
HCN,
CNG
Compressed natural gas (CNG) is a fuel gas mainly composed of methane (CH4), compressed to less than 1% of the volume it occupies at standard atmospheric pressure. It is stored and distributed in hard containers at a pressure of , usually in cy ...
,
CatSper
The cation channels of sperm also known as Catsper channels or CatSper, are ion channels that are related to the two-pore channels and distantly related to TRP channels. The four members of this family form voltage-gated Ca2+ channels tha ...
, and
TRP channels. This large group of ion channels apparently includes families , , , and of the
TCDB transporter classification.
They are described as minimally having two
transmembrane helices
A transmembrane domain (TMD) is a membrane-spanning protein domain. TMDs generally adopt an alpha helix topological conformation, although some TMDs such as those in porins can adopt a different conformation. Because the interior of the lipid bi ...
flanking a loop which determines the
ion selectivity of the channel pore. Many eukaryotic channels have four additional transmembrane helices (TM) (), related to or
vestigial
Vestigiality is the retention, during the process of evolution, of genetically determined structures or attributes that have lost some or all of the ancestral function in a given species. Assessment of the vestigiality must generally rely on co ...
of
voltage gating. The proteins with only two transmembrane helices () are most commonly found in bacteria. This also includes the 2-TM
inward-rectifier potassium channel
Inward-rectifier potassium channels (Kir, IRK) are a specific lipid-gated subset of potassium channels. To date, seven subfamilies have been identified in various mammalian cell types, plants, and bacteria. They are activated by phosphatidylino ...
s () found primarily in eukaryotes. There are commonly additional regulatory domains which serve to regulate ion conduction and channel gating. The pores may also be
homotetramers or
heterotetramer
A tetrameric protein is a protein with a quaternary structure of four subunits (tetrameric). Homotetramers have four identical subunits (such as glutathione S-transferase), and heterotetramers are complexes of different subunits. A tetramer ca ...
s; where heterotetramers may be encoded as distinct genes or as multiple pore domains within a single polypeptide. The
HVCN1 and
Putative tyrosine-protein phosphatase proteins do not contain an expected ion conduction pore domain, but rather have homology only to the voltage sensor domain of
voltage gated ion channels.
Human channels with 6 TM helices
Cation
Transient receptor potential
= Canonical
=
*
TRPC1
Transient receptor potential canonical 1 (TRPC1) is a protein that in humans is encoded by the ''TRPC1'' gene.
Function
TRPC1 is an ion channel located on the plasma membrane of numerous human and animal cell types.
It is a nonspecific cation ...
;
TRPC3
Short transient receptor potential channel 3 (TrpC3) also known as transient receptor protein 3 (TRP-3) is a protein that in humans is encoded by the TRPC3 gene. The TRPC3/6/7 subfamily are implicated in the regulation of vascular tone, cell growt ...
;
TRPC4;
TRPC5
Short transient receptor potential channel 5 (TrpC5) also known as transient receptor protein 5 (TRP-5) is a protein that in humans is encoded by the ''TRPC5'' gene. TrpC5 is subtype of the TRPC family of mammalian transient receptor potential io ...
;
TRPC6
Transient receptor potential cation channel, subfamily C, member 6, also known as TRPC6, is a human gene encoding a protein of the same name. TRPC6 is a transient receptor potential channel of the classical TRPC subfamily. It has been associated ...
;
TRPC7
Transient receptor potential cation channel, subfamily C, member 7, also known as TRPC7, is a human gene encoding a protein of the same name.
See also
* TRPC
TRPC is a family of transient receptor potential cation channels in animals.
TRPC ch ...
= Melastatin
=
*
TRPM1
Transient receptor potential cation channel subfamily M member 1 is a protein that in humans is encoded by the ''TRPM1'' gene.
Function
The protein encoded by this gene is a member of the transient receptor potential (TRP) family of non-select ...
;
TRPM2
Transient receptor potential cation channel, subfamily M, member 2, also known as TRPM2, is a protein that in humans is encoded by the ''TRPM2'' gene.
Structure
The protein encoded by this gene is a non-selective calcium-permeable cation channel ...
;
TRPM3
Transient receptor potential cation channel subfamily M member 3 is a protein that in humans is encoded by the ''TRPM3'' gene.
Function
The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels ...
;
TRPM4;
TRPM5;
TRPM6;
TRPM7
Transient receptor potential cation channel, subfamily M, member 7, also known as TRPM7, is a human gene encoding a protein of the same name.
Function
TRPs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ...
;
TRPM8
Transient receptor potential cation channel subfamily M (melastatin) member 8 (TRPM8), also known as the cold and menthol receptor 1 (CMR1), is a protein that in humans is encoded by the ''TRPM8'' gene. The TRPM8 channel is the primary molecular ...
= Vanilloid
=
*
TRPV1
The transient receptor potential cation channel subfamily V member 1 (TrpV1), also known as the capsaicin receptor and the vanilloid receptor 1, is a protein that, in humans, is encoded by the ''TRPV1'' gene. It was the first isolated member of th ...
;
TRPV2
TRPV is a family of transient receptor potential cation channels (TRP channels) in animals. All TRPVs are highly calcium selective.
TRP channels are a large group of ion channels consisting of six protein families, located mostly on the plasma ...
;
TRPV3
Transient receptor potential cation channel, subfamily V, member 3, also known as TRPV3, is a human gene encoding the protein of the same name.
The TRPV3 protein belongs to a family of nonselective cation channels that function in a variety of pro ...
;
TRPV4
Transient receptor potential cation channel subfamily V member 4 is an ion channel protein that in humans is encoded by the ''TRPV4'' gene.
The ''TRPV4'' gene encodes TRPV4, initially named "vanilloid-receptor related osmotically activated channe ...
;
TRPV5
Transient receptor potential cation channel subfamily V member 5 is a calcium channel protein that in humans is encoded by the ''TRPV5'' gene.
Function
The ''TRPV5'' gene is a member of the transient receptor family and the TRPV subfamily. The ...
;
TRPV6
TRPV6 is a membrane calcium (Ca2+) channel protein which is particularly involved in the first step in Ca2+absorption in the intestine.
Classification
Transient Receptor Potential Vanilloid subfamily member 6 (TRPV6) is an epithelial Ca2+ cha ...
= Mucolipin
=
*
MCOLN1;
MCOLN2;
MCOLN3;
= Ankyrin
=
*
TRPA1
Transient receptor potential cation channel, subfamily A, member 1, also known as transient receptor potential ankyrin 1, TRPA1, or The Wasabi Receptor, is a protein that in humans is encoded by the ''TRPA1'' (and in mice and rats by the ''Trpa1' ...
= TRPP
=
*
PKD1L3;
Calcium
Voltage-dependent
*
CACNA1A
Cav2.1, also called the P/ Q voltage-dependent calcium channel, is a calcium channel found mainly in the brain. Specifically, it is found on the presynaptic terminals of neurons in the brain and cerebellum. Cav2.1 plays an important role in con ...
;
CACNA1B;
CACNA1C
Calcium channel, voltage-dependent, L type, alpha 1C subunit (also known as Cav1.2) is a protein that in humans is encoded by the ''CACNA1C'' gene. Cav1.2 is a subunit of L-type voltage-dependent calcium channel.
Structure and function
This g ...
;
CACNA1D;
CACNA1E;
CACNA1F;
CACNA1G;
CACNA1H;
CACNA1I
Calcium channel, voltage-dependent, T type, alpha 1I subunit, also known as CACNA1I or Cav3.3 is a protein which in humans is encoded by the ''CACNA1I'' gene.
Function
Voltage-dependent calcium channels can be distinguished based on their volta ...
;
CACNA1S
Sperm
*
CATSPER1
CatSper1, is a protein which in humans is encoded by the ''CATSPER1'' gene. CatSper1 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca2+-permeant ion channel specific essential ...
;
CATSPER2
CatSper2, is a protein which in humans is encoded by the ''CATSPER2'' gene. CatSper2 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca2+-permeant ion channel specific essential fo ...
;
CATSPER3
CatSper3, is a protein which in humans is encoded by the ''CATSPER3'' gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' ...
;
CATSPER4
CatSper4, is a protein which in humans is encoded by the ''CATSPER4'' gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' ...
Ryanodine receptor
*
RYR1
Ryanodine receptor 1 (RYR-1) also known as skeletal muscle calcium release channel or skeletal muscle-type ryanodine receptor is one of a class of ryanodine receptors and a protein found primarily in skeletal muscle. In humans, it is encoded by ...
;
RYR2
Ryanodine receptor 2 (RYR2) is one of a class of ryanodine receptors and a protein found primarily in cardiac muscle. In humans, it is encoded by the ''RYR2'' gene. In the process of cardiac calcium-induced calcium release, RYR2 is the major medi ...
;
RYR3
Ryanodine receptor 3 is one of a class of ryanodine receptors and a protein that in humans is encoded by the ''RYR3'' gene. The protein encoded by this gene is both a calcium channel and a receptor for the plant alkaloid ryanodine. RYR3 and RY ...
Potassium
Voltage-gated potassium
= Delayed rectifier
=
*K
vα1.x -
Shaker-related: K
v1.1 (
KCNA1
Potassium voltage-gated channel subfamily A member 1 also known as Kv1.1 is a shaker related voltage-gated potassium channel that in humans is encoded by the ''KCNA1'' gene. Isaacs syndrome is a result of an autoimmune reaction against the Kv1 ...
), K
v1.2 (
KCNA2
Potassium voltage-gated channel subfamily A member 2 also known as Kv1.2 is a protein that in humans is encoded by the ''KCNA2'' gene.
Function
Potassium channels represent the most complex class of voltage-gated ion channels from both function ...
), K
v1.3 (
KCNA3
Potassium voltage-gated channel, shaker-related subfamily, member 3, also known as KCNA3 or Kv1.3, is a protein that in humans is encoded by the ''KCNA3'' gene.
Potassium channels represent the most complex class of voltage-gated ion channels fro ...
), K
v1.5 (
KCNA5
Potassium voltage-gated channel, shaker-related subfamily, member 5, also known as KCNA5 or Kv1.5, is a protein that in humans is encoded by the ''KCNA5'' gene.
Function
Potassium channels represent the most complex class of voltage-gated ion ...
), K
v1.6 (
KCNA6
Potassium voltage-gated channel subfamily A member 6 also known as Kv1.6 is a protein that in humans is encoded by the ''KCNA6'' gene. The protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of ...
), K
v1.7 (
KCNA7), K
v1.8 (
KCNA10
Potassium voltage-gated channel subfamily A member 10 also known as Kv1.8 is a protein that in humans is encoded by the ''KCNA10'' gene. The protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains o ...
)
*K
vα2.x - Shab-related: K
v2.1 (
KCNB1
Potassium voltage-gated channel, Shab-related subfamily, member 1, also known as KCNB1 or Kv2.1, is a protein that, in humans, is encoded by the ''KCNB1'' gene.
Potassium voltage-gated channel subfamily B member one, or simply known as KCNB1, is ...
), K
v2.2 (
KCNB2
Potassium voltage-gated channel subfamily B member 2 is a protein that in humans is encoded by the ''KCNB2'' gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.
Research
Limited research has been performed for ...
)
*K
vα3.x - Shaw-related: K
v3.1 (
KCNC1
Potassium voltage-gated channel subfamily C member 1 is a protein that in humans is encoded by the ''KCNC1'' gene.
The Shaker gene family of ''Drosophila'' encodes components of voltage-gated potassium channels and comprises four subfamilies. Base ...
), K
v3.2 (
KCNC2)
*K
vα7.x: K
v7.1 (
KCNQ1
Kv7.1 (KvLQT1) is a potassium channel protein whose primary subunit in humans is encoded by the ''KCNQ1'' gene. Kv7.1 is a voltage and lipid-gated potassium channel present in the cell membranes of cardiac tissue and in inner ear neurons among ...
) -
KvLQT1
Kv7.1 (KvLQT1) is a potassium channel protein whose primary subunit in humans is encoded by the ''KCNQ1'' gene. Kv7.1 is a voltage and lipid-gated potassium channel present in the cell membranes of cardiac tissue and in inner ear neurons among ...
, K
v7.2 (
KCNQ2
Kv7.2 (KvLQT2) is a voltage- and lipid-gated potassium channel protein coded for by the gene KCNQ2.
It is associated with benign familial neonatal epilepsy.
Function
The M channel is a slowly activating and deactivating potassium channel th ...
), K
v7.3 (
KCNQ3
Kv7.3 (KvLQT3) is a potassium channel protein coded for by the gene KCNQ3.
It is associated with benign familial neonatal epilepsy.
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regul ...
), K
v7.4 (
KCNQ4
Potassium voltage-gated channel subfamily KQT member 4, also known as voltage-gated potassium channel subunit Kv7.4, is a protein that in humans is encoded by the ''KCNQ4'' gene.
Function
The protein encoded by this gene forms a potassium chann ...
), K
v7.5 (
KCNQ5)
*K
vα10.x: K
v10.1 (
KCNH1
Potassium voltage-gated channel subfamily H member 1 is a protein that in humans is encoded by the ''KCNH1'' gene.
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and struct ...
)
= A-type potassium
=
*K
vα1.x - Shaker-related: K
v1.4 (
KCNA4
Potassium voltage-gated channel subfamily A member 4 also known as Kv1.4 is a protein that in humans is encoded by the ''KCNA4'' gene. It contributes to the cardiac transient outward potassium current (Ito1), the main contributing current to the ...
)
*K
vα3.x - Shaw-related: K
v3.3 (
KCNC3), K
v3.4 (
KCNC4)
*K
vα4.x - Shal-related: K
v4.1 (
KCND1
Potassium voltage-gated channel, Shal-related subfamily, member 1 (KCND1), also known as Kv4.1, is a human gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." ...
), K
v4.2 (
KCND2
Potassium voltage-gated channel subfamily D member 2 is a protein that in humans is encoded by the ''KCND2'' gene. It contributes to the cardiac transient outward potassium current (Ito1), the main contributing current to the repolarizing phase ...
), K
v4.3 (
KCND3
Potassium voltage-gated channel subfamily D member 3 also known as Kv4.3 is a protein that in humans is encoded by the ''KCND3'' gene. It contributes to the cardiac transient outward potassium current (Ito1), the main contributing current to the r ...
)
= Outward-rectifying
=
*K
vα10.x: K
v10.2 (
KCNH5)
= Inwardly-rectifying
=
*K
vα11.x -
ether-a-go-go potassium channels
An Ether-a-go-go potassium channel is a Potassium channel which is Inwardly-rectifying and voltage-gated.
Examples include hERG
hERG (the human '' Ether-à-go-go''-Related Gene) is a gene () that codes for a protein known as Kv11.1, the alph ...
: K
v11.1 (
KCNH2
hERG (the human '' Ether-à-go-go''-Related Gene) is a gene () that codes for a protein known as Kv11.1, the alpha subunit of a potassium ion channel. This ion channel (sometimes simply denoted as 'hERG') is best known for its contribution to th ...
) -
hERG
hERG (the human '' Ether-à-go-go''-Related Gene) is a gene () that codes for a protein known as Kv11.1, the alpha subunit of a potassium ion channel. This ion channel (sometimes simply denoted as 'hERG') is best known for its contribution to th ...
, K
v11.2 (
KCNH6
Potassium voltage-gated channel subfamily H member 6 is a protein that in humans is encoded by the ''KCNH6'' gene. The protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residu ...
), K
v11.3 (
KCNH7)
= Slowly activating
=
*K
vα12.x: K
v12.1 (
KCNH8), K
v12.2 (
KCNH3), K
v12.3 (
KCNH4)
= Modifier/silencer
=
*K
vα5.x: K
v5.1 (
KCNF1)
*K
vα6.x: K
v6.1 (
KCNG1), K
v6.2 (
KCNG2), K
v6.3 (
KCNG3), K
v6.4 (
KCNG4)
*K
vα8.x: K
v8.1 (
KCNV1), K
v8.2 (
KCNV2)
*K
vα9.x: K
v9.1 (
KCNS1), K
v9.2 (
KCNS2), K
v9.3 (
KCNS3)
Calcium-activated
= BK
=
*
KCa1.1 (BK, Slo1, Maxi-K, )
= SK
=
* K
Ca2.x: K
Ca2.1 (
KCNN1
Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 , also known as KCNN1 is a human gene encoding the KCa2.1 protein.
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) t ...
) - SK1, K
Ca2.2 (
KCNN2
Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2, also known as KCNN2, is a protein which in humans is encoded by the KCNN2 gene. KCNN2 is an ion channel protein also known as KCa2.2.
Function
Action po ...
) - SK2, K
Ca2.3 (
KCNN3) - SK3
* K
Ca3.x: K
Ca3.1 (
KCNN4
Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4, also known as KCNN4, is a human gene encoding the KCa3.1 protein.
Function
The KCa3.1 protein is part of a potentially heterotetrameric voltage-independ ...
) - SK4
* K
Ca4.x: K
Ca4.1 (
KCNT1) - SLACK, K
Ca4.2 (
KCNT2
Potassium channel subfamily T, member 2, also known as KCNT2 is a human gene that encodes the KNa protein. KCNT2, also known as the Slick channel (sequence like an intermediate calcium channel) is an outwardly rectifying potassium channel activate ...
) - SLICK
= IK
=
*
KCa3.1 (IKCa1, SK4, )
= Other subfamilies
=
*
KCa5.1 (Slo3, )
Inward-rectifier potassium
Sodium
*
NALCN
*
SCN1A
Sodium channel protein type 1 subunit alpha (SCN1A), is a protein which in humans is encoded by the ''SCN1A'' gene.
Gene location
The SCN1A gene is located on chromosome 2 of humans, and is made up of 26 exons spanning a total length of 6030 nu ...
;
SCN2A
SCN may stand for:
Science and technology
*Switched circuit network, i.e. the public switched telephone network
* Server change number, a counter variable used in client-server architecture
*System change number, a stamp that defines a committed ...
;
SCN2A2;
SCN3A
Sodium channel, voltage-gated, type III, alpha subunit (SCN3A) is a protein that in humans is encoded by the ''SCN3A'' gene.
Function
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit wi ...
;
SCN4A
Sodium channel protein type 4 subunit alpha is a protein that in humans is encoded by the ''SCN4A'' gene.
The Nav1.4 voltage-gated sodium channel is encoded by the gene. Mutations in the gene are associated with hypokalemic periodic paralys ...
;
SCN5A
Sodium channel protein type 5 subunit alpha, also known as NaV1.5 is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. NaV1.5 is found primarily in cardiac muscle, where it mediates the fast influx of N ...
;
SCN7A
Sodium channel protein type 7 subunit alpha is a protein that in humans is encoded by the ''SCN7A'' gene on the chromosome specifically located at 2q21-23 chromosome site.
This is one of 10 Sodium channel types, and is expressed in the heart, the u ...
;
SCN8A
Sodium channel protein type 8 subunit alpha also known as Nav1.6 is a membrane protein encoded by the ''SCN8A'' gene. Nav1.6 is one sodium channel isoform and is the primary voltage-gated sodium channel at each node of Ranvier. The channels are hi ...
;
SCN9A
Nav1.7 is a sodium ion channel that in humans is encoded by the ''SCN9A'' gene. It is usually expressed at high levels in two types of neurons: the nociceptive (pain) neurons at dorsal root ganglion (DRG) and trigeminal ganglion and sympatheti ...
;
SCN10A
Nav1.8 is a sodium ion channel subtype that in humans is encoded by the ''SCN10A'' gene.
Nav1.8-containing channels are tetrodotoxin (TTX)-resistant voltage-gated channels. Nav1.8 is expressed specifically in the dorsal root ganglion (DRG), in u ...
;
SCN11A
Sodium channel, voltage-gated, type XI, alpha subunit also known as SCN11A or Nav1.9 is a voltage-gated ion channel, voltage-gated sodium ion channel protein which is encoded by the ''SCN11A'' gene on Chromosome 3 (human), chromosome 3 in human ...
*
SLC9A10;
SLC9A11
Cyclic nucleotide-gated
*
CNGA1;
CNGA2;
CNGA3;
CNGA4
*
CNGB1;
CNGB3
*
HCN1;
HCN2;
HCN3;
HCN4
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 is a protein that in humans is encoded by the ''HCN4'' gene.
There are four HCN channels. HCN4 is prominently expressed in the pace maker region of the mammalian hear ...
*
ITPR1
Inositol 1,4,5-trisphosphate receptor type 1 is a protein that in humans is encoded by the ''ITPR1'' gene.
Interactions
ITPR1 has been shown to interact with:
* AHCYL1,
* CA8,
* EPB41L1
* FKBP1A,
* MRVI1,
* PRKG1,
* RHOA
Transform ...
;
ITPR2
Inositol 1,4,5-trisphosphate receptor, type 2, also known as ITPR2, is a protein which in humans is encoded by the ''ITPR2'' gene. The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.
See also
* I ...
;
ITPR3
Proton
*
HVCN1
Related proteins
*
TPTE, part of the larger
Voltage sensitive phosphatase
Voltage sensitive phosphatases or voltage sensor-containing phosphatases, commonly abbreviated VSPs, are a protein family found in many species, including humans, mice, zebrafish, frogs, and sea squirt.
Discovery
The first voltage sensitive pho ...
family
Human channels with 2 TM helices in each subunit
Potassium
Tandem pore domain potassium channel
*
KCNK1;
KCNK2
Potassium channel subfamily K member 2, also known as TREK-1, is a protein that in humans is encoded by the ''KCNK2'' gene.
This gene encodes K2P2.1, a lipid-gated ion channel belonging to the two-pore-domain background potassium channel protein ...
;
KCNK3
Potassium channel subfamily K member 3 is a protein that in humans is encoded by the ''KCNK3'' gene.
This gene encodes K2P3.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K2P3.1 is an ...
;
KCNK4
Potassium channel subfamily K member 4 is a protein that in humans is encoded by the ''KCNK4'' gene. KCNK4 protein channels are also called TRAAK channels.
Function
''KNCK4'' is a gene segment that encodes for the TRAAK (TWIK-related Arachidon ...
;
KCNK5;
KCNK6;
KCNK7
Potassium channel, subfamily K, member 7, also known as KCNK7 or K2P7.1 is a protein which is encoded in humans by the ''KCNK7'' gene. K2P7.1 is a potassium channel containing two pore-forming P domains. Multiple transcript variants encoding dif ...
;
KCNK9
Potassium channel subfamily K member 9 is a protein that in humans is encoded by the ''KCNK9'' gene.
This gene encodes K2P9.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This open ch ...
;
KCNK10
Potassium channel, subfamily K, member 10, also known as KCNK10 is a human gene. The protein encoded by this gene, K2P10.1, is a potassium channel containing two pore-forming P domains.
See also
* Tandem pore domain potassium channel
The two ...
;
KCNK12
Potassium channel, subfamily K, member 12, also known as KCNK12 is a human gene. The protein encoded by this gene, K2P12.1, is a potassium channel containing two pore-forming P domains.
See also
* Tandem pore domain potassium channel
The two-p ...
;
KCNK13
Potassium channel, subfamily K, member 13, also known as KCNK13 is a human gene. The protein encoded by this gene, K2P13.1 is a potassium channel containing two pore-forming P domains.
See also
* Tandem pore domain potassium channel
The two-po ...
;
KCNK15
Potassium channel subfamily K member 15 is a protein that in humans is encoded by the ''KCNK15'' gene.
This gene encodes K2P15.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K2P15.1 ha ...
;
KCNK16
Potassium channel subfamily K member 16 is a protein that in humans is encoded by the ''KCNK16'' gene. The protein encoded by this gene, K2P16.1, is a potassium channel containing two pore-forming P domains.
See also
* Tandem pore domain potassi ...
;
KCNK17
Potassium channel subfamily K member 17 is a protein that in humans is encoded by the ''KCNK17'' gene.
This gene encodes K2P17.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This open ...
;
KCNK18
Potassium channel subfamily K member 18 (KCNK18), also known as TWIK-related spinal cord potassium channel (TRESK) or K2P18.1 is a protein that in humans is encoded by the ''KCNK18'' gene. K2P18.1 is a potassium channel containing two pore-formin ...
Non-human channels
Two-pore
*
TPCN1
*
TPCN2
Pore-only potassium
*
KcsA
Ligand-gated potassium
* GluR0
Voltage-gated potassium
* KvAP
Prokaryotic KCa
* Kch
* MthK
* TrkA/TrkH
* KtrAB
* GsuK
* TM1088
Voltage and cyclic nucleotide gated potassium
* MlotiK1
Sodium
* NaChBac
* NaVAb
* NaVAe1
* NaVAp
* NaVMm
Non-selective
* NaK
Prokaryotic inward-rectifier potassium
* KirBac
Engineered
* NaK2CNG
* NaK2K
References
External links
*
{{InterPro content, IPR005821
Protein domains
Protein families
Transmembrane proteins
Ion channels